Preheat your oven to 375°F (190°C). Line a baking sheet with parchment paper.
In a skillet over medium heat, cook the ground beef. Add Worcestershire sauce, garlic powder, onion powder, salt, and pepper. Cook until browned, then remove from heat.
Flatten each biscuit into a round disc. Place a spoonful of beef mixture and a pinch of cheddar cheese in the center.
Fold the edges of the biscuit around the filling and pinch to seal. Place seam-side down on the baking sheet.
Mix melted butter, minced garlic, and Parmesan. Brush each biscuit bomb with the mixture.
Bake for 15–18 minutes, or until golden brown. Sprinkle with parsley if using.
Let cool slightly and serve warm with your favorite dipping sauces.